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High-throughput automated system for statistical biosensing employing microcantilever arrays

机译:用于统计生物调强的高吞吐量自动化系统,采用Microcantilever阵列

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In this paper we present a completely new and fully automated system for parallel microcantilever-based biosensing. Our platform is able to monitor simultaneously the change of resonance frequency (dynamic mode), of deflection (static mode), and of surface roughness of hundreds of cantilevers in a very short time over multiple biochemical reactions. We have proven that our system is capable to measure 900 independent microsensors in less than a second. Here, we report statistical biosensing results performed over a haptens-antibody assay, where complete characterization of the biochemical binding on the cantilever surfaces is obtained with higher accuracy than standard optical lever-based setups.
机译:在本文中,我们提供了一种全新的和全自动系统,可用于平行的基于微电子的生物传感。我们的平台能够同时监测偏转频率(动态模式)的变化,偏转(静态模式)以及数百种悬臂的表面粗糙度在很短的时间内在多个生化反应上的情况下。我们证明,我们的系统能够在不到一秒钟内测量900个独立的微传感器。在这里,我们报告通过Haptens-抗体测定进行的统计生物抑制结果,其中通过比标准光学杆的设置更高的精度获得悬臂表面上的生物化学结合的完整表征。

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