Analogs of Multifunctional Ligands for Opioid and CCK Receptors

摘要

Recently, our group introduced a new paradigm in drug design for the treatment of pain in the disease stat. Biologically, many disease states lead to changes in expressed proteins, therefore, "system changes" that occur must be considered in any treatment for the disease. This new approach to drug design and discovery would be particularly applicable to the diseases that involve adaptive changes in the central nervous system, such as neuropathic pain. There is growing evidence that drugs behave differently in pathological states than in normal states, thus preventing their effectiveness in pathological disease states. Therefore, a new paradigm for drug design is needed.