Design, Synthesis, and Evaluation of Gluten Peptide Analogs as Selective Inhibitors of Human TG2

摘要

Celiac Sprue is an inflammatory disease of the small intestine that causes the destruction of the intestinal villi with severe consequences for the growth and the health of the organism. The pathogenesis of this disease is initiated by the ingestion of the gluten held in different cereals. At present the only therapy is a gluten-free diet. Therefore, to find a pharmacological alternative is an important and urgent objective.