Alamethicin Interaction with Lipid Membranes: A Spectroscopic Study on Synthetic Analogs

摘要

Alamethicin is one of the most extensively studied membrane-active antibiotic peptides. However, several aspects of its mechanism of action are still debated. To investigate the effect of peptide hydrophobicity on its membrane-perturbing activity and to determine the peptide position and orientation inside the lipid bilayer, we have employed synthetic analogs of alamethicin F50/5 (Fig. 1).