Synthesis and Biological Activities of Proline Rich Cyclic Heptapeptide Hymemanide B Analogs

摘要

The isolation of a great variety of biological active materials from marine organisms has been reported. Many types of these bioactive compounds are cyclic peptides. Cyclic peptides have metabolic stabilities and restricted conformations. Since these characters play a key role for biological activities, cyclic peptides have been the focus as pharmacological targets. One class of these cyclic peptides, named hymenamides, has been isolated from Okinawan marine sponge Hymeniacidon sp. . This peptide family contains proline and hydrophobic residues with high frequency and shows high cytotoxic activity, antifungal activity, and occasionally works as enzymatic inhibitor. However, it is difficult to secure enough amounts of natural product for physiological estimation by isolation. Therefore, to further explore these peptides, it is necessary to chemically synthesize them to obtain sufficient amounts to perform structure-function relationships studies.