Synthesis of Cyclic Tetrapeptide CJ 15,208: A Novel Kappa Opioid Receptor Antagonist

摘要

Kappa (k) opioid receptor (KOP) ligands are of considerable interests for the development of potential therapeutic agents [1]. The KOP antagonists have demonstrated promising activity in stress-induced cocaine seeking behavior [2,3] and a functional KOP antagonist has shown activity for the treatment of opiate abuse [4]. In addition KOP antagonists exhibit anti-depressant activity in animal models [5]. Thus KOP antagonists are potentially useful as therapeutic agents in the treatment of drug abuse and depression.