Electrical Double Layer Gated Field Effect Transistor Biosensors for the Quantitative Detection of Beta-Human Chorionic Gonadotropin

摘要

In this research, we have developed biosensors to detect beta human chorionic gonadotropin (beta-HCG) which is a hormone widely used to test for pregnancy and also serves as a biomarker for risk assessment of certain types of cancers. The biosensor methodology is based on extended gate design of electrical double layer (EDL) gated field effect transistor (FET). The sensor demonstrates a very wide dynamic range of detection, with a very low detection limit, which shows the potential of our sensor to detect pregnancies in very early stages. Furthermore, this sensor platform can enable the use of beta-HCG for risk stratification of cancers as well. The sensor can be batch produced and does not use additional labels/reagents or sample pre-processing techniques, which can greatly enhance the cost-effectiveness, comparable to the current commercialized beta-HCG assays.