ADVANCES IN TOXICOLOGY: THE USE OF INTRA-LIPID THERAPY HIGH-DEXTROSE INSULIN THERAPY

摘要

The use of intravenous lipid emulsion (ILE) or intravenous fat emulsion (IFE) has been well utilized in both human and veterinary medicine for decades as part of component therapy in the form of either total (TPN) or partial parenteral nutrition (PPN). More recently, the use of IFE has been utilized as an antidote for fat-soluble drug toxicity, particularly with local anesthesia overdoses in human medicine (i.e., bupivacaine), where acute cardiopulmonary arrest has occurred. Numerous published case reports and experimental studies describe the beneficial use of IFE in the treatment of patients intoxicated with other drugs, including verapamil, bupoprion, lamotrigine, quetiapine, sertraline, calcium-channel blockers, and beta-blockers.