Blood components characterization for pre-analytical rapid quality controls through impedance measurements

摘要

In clinical laboratories the requirements for quality control material have greatly increased in order to evaluate and monitor the reliability of performances. Pre-analytical conditions of blood samples are key factors in maintaining the high quality of the specimens and they are necessary for the reproducibility and the accuracy of measurements and procedures in clinic. Using quality control samples, day-to-day and batch variations can be limited. The quality of the serum has to be very high in order to avoid interferences due to hemolysis; for this reason, every sample should be rapidly tested with smart and port-able devices. In addition, the quality of whole blood preservation should be quantified in a fast way to guarantee the complete compatibility and avoid anomalies, for example before blood transfusion. A new simple impedance-based biosensor is proposed for ensuring the reliability of patient sample results. Comparing and combining the data of impedance measurements, this technique has been applied for the fast discrimination of different blood components, the identification of hemolysis in serum samples and the rapid and automatic evaluation of blood quality, as demonstrated by the presented preliminary results.