Residues of veterinary drugs: APRAMYCIN

摘要

Apramycin (Chemical Abstracts Service No. 65710-07-8) is a broad-spectrum aminocyclitol antibiotic produced by a strain of Streptomyces tenebrarius. It is effective against both Gram-positive and Gram-negative bacteria, including isolates of Escherichia coli and Salmonella species, and some strains of mycoplasma from farm animals and human origin. Apramycin is extracted from the fermentation medium as apramycin sulfate at a purity of at least 85%, and activity is expressed as equivalents of apramycin base using a microbiological assay.