Assessment of the long-duration effect of inhaled long-acting bronchodilator Salmeterol on cardiac autonomic control in adult asthma patients

摘要

The asthma patients usually received regular use of inhaled corticosteroid combined with long-acting ?? agonist (LABA) for their asthma control. The inhaled LABA achieved the bronchodilation effect through sympathetic activation in airways of asthma patients. These LABAs might have the cardiovascular effects such as palpitation, tachycardia and QTc prolongation. There are studies investigating the short-duration effect of LABA on cardiac autonomic control in asthma patients. However, the long-duration effect of inhaled LABA on cardiac autonomic control in adult asthma patients remains lacking. In this study, we explored the longduration effect of inhaled bronchodilator Salmeterol (one kind of LABAs) on cardiac autonomic control with heart rate variability (HRV) analysis in adult asthma patients. Serial resting, surface ECGs were recorded at different time intervals (from baseline to 180th min) after inhalation of Salmeterol in eligible adult asthma patients. Mean heart rate (mean RR), standard deviation of normal RR interval (SDNN), normalized low frequency band power (LFn), normalized high frequency band power (HFn) and the ratio LF/HF were obtained from analysis of heart rate variability (HRV) at these different time intervals.