SUGAR AMINO ACIDS - SYNTHESIS AND CONFORMATIONAL ANALYSIS OF DIMETHYL 3-AMINO-2,3-DIDEOXYHEXOPYRANOSIDURONATES

摘要

Sugar amino acids (SAAs) are sugar moieties containing at least one amino and one carboxyl group. Such compounds are important class of polyfunctional scaffolds where the carboxyl, amino and hydroxyl termini allow to create structural diversities akin to biologically active molecules. The rigid pyranose ring system of monosaccharide amino acid can be used as molecular template to display pharmacophoric groups in well defined spatial orientation. Additionally, sugar amino acids have been used extensively in the area of peptidomimetic studies.