THE PEPTAIBIOME AND PEPTAIBOMICS. STRUCTURAL CHARACTERIZATION OF THE ENTIRETY OF PEPTAIBIOTICS EXPRESSED BY FUNGI

摘要

In analogy to the terms "proteome" and "proteomics" we define the "peptaibiome" as the entirety of fungal peptides containing the non-protein α-aminoisobutyric acid (Aib). Accordingly, "peptaibiomics" is the analytical methodology for the structural characterization of the entirety of peptaibiotics expressed in filamentous fungi . A peptaibiotic is defined as fungal peptide containing Aib and exhibiting antibiotic or other bioactivities. Peptaibiotics consists of mixtures containing up to twenty residues peptides that have, in part, unusual N- and C-termini. We present a rapid and sensitive method for the detection and structural characterization of the peptaibiome expressed by fungal multienzyme complexes .