SINGLE AMINO ACID SUBSTITUTION ANALOGUES OF THE ANTIBACTERIAL PEPTIDE A7-ANOPLIN

摘要

Anoplin, GLLKRIKTLL-NH2, is an antibacterial peptide isolated from the solitary spider wasp, Anoplius samariensis . Previously, we have reported a structure-activity study of anoplin based on 37 analogues . Alanine positional scanning showed restrictions on 6 out of the 10 residues, and improved MIC values for the remaining 4 residues, including [A~7]-anoplin. In the present paper, we report a series of analogues of [A~7]-anoplin in which Ala was replaced by Val, Leu, Ile, Phe, Trp and Asn.