CYCLIC RENIN INHIBITOR CONTAINING 2-SUBSTITUTED (3S,4S)- 4-AMINO-5-CYCLOHEXYL-3-HYDROXYPENTANOIC ACID, 2-SUBSTITUTED (3S,4S)-5-CYCLOHEXYL-3,4-DIHYDROXYPENTANOIC ACID OR 2-SUBSTITUTED(4S,5S)-5-AMINO-6-CYCLOHEXYL-4-HYDROXY- HEXANOIC ACID OR THEIR ANALOGUES

摘要

Compounds of the formula: CHEM are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.