LONG-TERM INTERACTION BETWEEN β-AMYLOID FIBRILS AND SHORT PEPTIDES

摘要

Aggregates of β-amyloid peptide (Aβ) play central role in Alzheimer's disease (AD). Soto's pentapeptide LPFFD and our LPYFD-amide (LPYFD-NH2) are effective neuroprotective agents against Aβ assemblies both in vitro and in vivo, These short peptides can interact with Aβ peptides but the nature of the interaction has not proved yet (β-sheet breakers, molecular surface covering substances or other effects?). The main aims of these studies were to follow the aggregation process of Aβ_(1-42) from oligomers /monomer to matured fibrils, to study the interaction between short peptides (LPFFD and LPYFD-NH2) and Aβ_(1-42), and to understand the neuroprotective effect of Soto's LPFFD and our LPFYD-NH2 pentapeptides.