Analysing covalent protein-drug adducts: protein-melphalan adducts

摘要

Many drugs form reactive electrophilic intermediates or metabolites in the body, often through metabolic activation. This has raised some questions because of the link between unspecific covalent binding of these drugs to proteins and possible adverse drug reactions (ADR). We want to develop specific detection and characterization techniques in order to get a better picture of the formation of these covalent protein-drug adducts. Improved understanding of this adduct formation and its effects could enhance drug efficacy and safety.