LC-MS1 METHOD FOR PROTEIN IDENTIFICATION AND QUANTITATION WITHOUT USING TANDEM MASS SPECTRA

摘要

A major bottleneck of modern shotgun proteomics is limitation of fragment mass spectra acquisition speed. We present a novel workflow for protein identification based on LC-MS1 analysis with no using of tandem mass-spectra [1]. The proposed method has no drawbacks of accurate mass tags (AMT)or classic peptide-mass fingerprinting approaches.