CHARGE-INDEPENDENT MASS SPECTROMETRY OF SINGLE VIRUS CAPSIDS ABOVE 100MDA WITH NANOMECHANICAL RESONATORS

摘要

Nanomechanical resonators can measure the mass of individual particles accreting on their surface [1]. As their frequency-to-mass relationship scales inversely with the resonator's dimension, research groups have engaged in a race to measure the smallest detectable mass with increasingly small resonators [2]. However, nanomechanical resonators have best performances in the MDa to GDa mass range, where most technologies, including MS, struggle to measure masses.