ALDOSTERONE SPECIFIC VISUALIZATION IN PRIMARY ALDOSTERONISM USING IMAGING MASS SPECTROMETRY

摘要

Visualization of steroid hormones using MALDI-IMS is one of the active subjects for endocrine studies. Unfortunately, it is difficult to detect steroid hormones due to the low polarity. To overcome the problems, on-tissue chemical derivatization (OTCD) was developed [1], however the problem of structural isomers in steroid hormones is still remain. Herein, we introduce aldosterone specific visualization method using OTCD and tandem MS.