QUANTITATIVE PROTEOMIC ANALYSIS OF CERVICOVAGINAL FLUID PROTEOME USING A 2D-NLCESI-MS/MS FOR EARLY DETECTION OF PRETERM BIRTH

摘要

Preterm birth (PTB) before 37 weeks of pregnancy is one of major causes of perinatal mortality and neonatal morbidity. Despite of previous studies in developing biomarker(s) of PTB [1-3], unfortunately, the valuable protein maker for the early detection of PTB has not been unveiled. In this study, we performed quantitative profiling of cervicovaginal fluid (CVF) proteome for discovery of PTB-specific marker(s) via online 2D-nLC-ESI-MS/MS with isobaric labeling.