CHALLENGES OF LIPID ISOMERS AND ISOBARS IN MASS SPECTROMETRY-BASED BIOMARKER RESEARCH

摘要

Interfering isobaric & isomeric species still constitute a major issue in the unambiguous attribution of lipid biomarkers to disease. MRM scanning allows to distinguish the main lipid classes, but not always isobaric subclasses. HRAM spectrometry (MS1) allows the distinction of these isobaric species but is not able to distinguish isomers. We are comparing two flow-injection analysis methods.