MYELIN PROTEOMICS 2.0: APPLICATION TO MOUSE MODELS FOR MYELIN-RELATED DISEASES

摘要

Myelin, a plasma membrane specialization of glial cells, facilitates rapid signaling in the nervous system. A key tool to approach failing glia-axonal support in neurological disorders is the proteome analysis of myelin, but membrane protein content and dynamic range pose technical challenges (reviewed in [1,2]). We show advances in label-free quantification of myelin proteins and applications to a mouse model for a heritable peripheral neuropathy.