Carbohydrate ligands that bind IgM antibodies to myelin-related glycoproteins

摘要

The present invention relates to carbohydrate ligands that present minimal human natural killer-1 (HNK-1) epitopes that bind to anti-MAG (myelin-associated glycoprotein) IgM antibodies, and in the diagnosis of anti-MAG neuropathies and to the treatment of anti-MAG neuropathies. Regarding these uses for. In particular, the invention relates to disaccharides of formula (I) and (II), wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl, or heteroarylmethyl, and formula (I) And / or a therapeutically acceptable polymer comprising a number of substituents of formula (II), wherein Z is a bifunctional linker linking the disaccharide to the polymer backbone. [Selection figure] None