- IgM CARBOHYDRATE LIGANDS THAT BIND TO IGM ANTIBODIES AGANIST MYELIN-ASSOCIATED GLYCOPROTEIN

摘要

The present invention provides a method for diagnosing a carbohydrate ligand exhibiting a minimal human natural killer-1 (HNK-1) antigenic determinant binding to an anti-MAG (myelin-related glycoprotein) IgM antibody, and anti- Lt; / RTI In particular, the invention relates to compounds of formula (I) and / or (II), wherein Z is optionally substituted phenyl, heteroaryl, arylcarbonyl or heteroarylmethyl, A therapeutically acceptable polymer comprising a plurality of substituents of formula (II) wherein Z is a bifunctional linker linking the disaccharide to the polymer backbone: