LIQUID EXTRACTION SURFACE ANALYSIS AND DIRECT ESI/NANOESI MASS SPECTROMETRY FOR HIGH THROUGHPUT URINARY METABOLOMICS APPLIED TO MALARIA

摘要

Direct electrospray/nano-electrospray ionisation mass spectrometry (ESI/nanoESI-MS) have great potential as high-throughput approaches for untargeted urine metabolomics [1-5]. Here, we compare standard liquid chromatography-mass spectrometry (LC-MS) with ambient ionisation MS methods of liquid extraction surface analysis MS (LESA-MS), flow injection ESI-MS (FIE-MS)and nanoESI-chip-based infusion for clinical urinary metabolomics.