EPITOPE AND AFFINITY DETERMINATION OF RECOMBINANT MYCOBACTERIUM TUBERCULOSIS AG85B ANTIGEN TOWARDS ANTI-AG85 ANTIBODIES USING PROTEOLYTIC-AFFINITY MASS SPECTROMETRY AND BIOSENSOR ANALYSIS

摘要

Tuberculosis (TB) is the first cause of death from infectious diseases worldwide. Only a single anti-TB vaccine is currently available for clinical use, but its efficacy is not achieved with certainty [1]. The aim of this work is to provide a basis for the rational design of a neo-glycoconjugate vaccine against TB.