首页> 外国专利> Isolated dna molecule isolated protein or polypeptide process to vaccinate mammals against mycobacterium tuberculosis infection recombinant dna expression system vaccine host to prevent infection and mammalian disease by mycobacterium tuberculosis process to vaccinate mammals isolated antibody or binding moiety same process and composition to passively imminate mammals infected with mycobacterium tuberculosis processes to detect mycobacterium tuber

Isolated dna molecule isolated protein or polypeptide process to vaccinate mammals against mycobacterium tuberculosis infection recombinant dna expression system vaccine host to prevent infection and mammalian disease by mycobacterium tuberculosis process to vaccinate mammals isolated antibody or binding moiety same process and composition to passively imminate mammals infected with mycobacterium tuberculosis processes to detect mycobacterium tuber

机译:分离的dna分子分离的蛋白质或多肽过程,用于对哺乳动物进行结核分枝杆菌感染的疫苗接种重组dna表达系统疫苗宿主,用于预防分枝杆菌的感染和哺乳动物疾病,以对哺乳动物分离的抗体或结合部分进行疫苗接种,相同的过程和组成,以被动地模仿被分枝杆菌感染的哺乳动物检测结核分枝杆菌的结核病过程

摘要

The present invention relates to a DNA molecule conferring on Mycobacterium tuberculosis an ability to enter mammalian cells and to survive within macrophages. The protein encoded by this gene fragment is useful in vaccines to prevent infection by Mycobacterium tuberculosis, while the antibodies raised against this protein can be employed in passively immunizing those already infected by the organism. Both these proteins and antibodies may be utilized in diagnostic assays to detect Mycobacterium tuberculosis in tissue or bodily fluids. The protein of the present invention can be associated with various other therapeutic materials, for administration to mammals, particularly humans, to achieve uptake of those materials by such cells.
机译:本发明涉及赋予结核分枝杆菌进入哺乳动物细胞并在巨噬细胞内存活的能力的DNA分子。由该基因片段编码的蛋白质可用于预防结核分枝杆菌感染的疫苗,而针对该蛋白质的抗体可用于被动免疫已被该生物体感染的抗体。这些蛋白质和抗体均可用于诊断测定,以检测组织或体液中的结核分枝杆菌。本发明的蛋白质可以与多种其他治疗材料相关联,以施用于哺乳动物,特别是人类,以实现被此类细胞摄取那些材料。

著录项

  • 公开/公告号BR9607406A

    专利类型

  • 公开/公告日1998-07-07

    原文格式PDF

  • 申请/专利权人 CORNELL RESEARCH FOUNDATION INC.;

    申请/专利号BR19969607406

  • 发明设计人 LEE W. RILEY;

    申请日1996-02-20

  • 分类号C12N15/31;C12N1/21;C12N15/70;C07K14/35;C07K16/12;A61K39/04;A61K39/395;G01N33/569;C12Q1/68;

  • 国家 BR

  • 入库时间 2022-08-22 02:58:34

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