Determination of 8 Estrogens in Milk by the 1290 UHPLC and Highly Sensitive 6495 Triple Quadrupole Mass Spectrometer

摘要

The high-sensitivity 6495 triple quadrupole MS is a potential tool for estrogens measurement in food matrices where MRLs are low. The advanced instrumentation allows the use of simpler sample preparation procedures as significant enrichment or derivatization is unnecessary. The impurities and observed matrix effect were minimal for the milk blank. This method has potential applications for the measurement of estrogens in other similar matrices, such as milk powder.