Nowadays ion mobility (IM) spectrometry attracts a lot of attention in analytical chemistry due to recent technical advances, which enable to conduct demanding experiments and develop new applications ranging from small molecules to biomacromolecules. The most popular combination is ion mobility - mass spectrometry (IM-MS), where IM could work either as the prefilter to remove the chemical noise or as another separation dimension for difficult analytical tasks, such as separation of isobaric species. Differential mobility spectrometry (DMS) is one variant of IM based on the use of two parallel conductive plates with applied asymmetric radio-frequency (RF) field, which is used in our work to investigate separation of triacylglycerol (TG) regioisomers.
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