Microwave-assisted Synthesis of Benzofpyrrolo1,2-aquinolines

摘要

Benzo[f]pyrrolo[1,2-a]quinoline is an interesting N-bridgehead heterocyclic system, structurally analogous to the steroid skeleton. Two ways are known for benzo[f]pyrrolo[1,2-a]quinoline synthesis. The first way starts from 3-ethoxycarbonyl-1-hydroxy-8-methoxybenzo[f]quinoline via a multi-step synthesis. The second route is based on 1,3-dipolar cycloaddition reactions of benzo[f]quinolinium-1-methylides, generated in situ from the corresponding benzo[f]quinolinium salts, with activated alkynes.