Preparation of 6-Heteroarylpurines by Cocyclotrimerizations of 6-(Diynyl)purines with Nitriles(Abstracts)

摘要

6-Arylpurine derivatives have diverse types of a biological activity: some substituted 6-arylpurine bases are antagonists of corticotropin-releasing hormone or possess antimycobacterial and antibacterial activity, while 6-arylpurine ribonucleosides are potent cytostatics. These facts explain, why it is worth being interested in the synthesis of this class of compounds. Our first synthetic strategy was focused on easily accessible starting materials: 6-alkynylpurines and α,ω-diynes, which undergo smooth cocyclotrimerization reaction in the presence of transition-metal phosphine complexes.