High Performance Thin Layer Chromatography (HPTLC) Coupled with DESI-Ion Mobility-Mass Spectrometry: A Novel Approach for Petroleum Characterisation

摘要

DESI-IM-MS was successfully employed for the analysis of petroleum samples separated by HPTLC. HPTLC separation of key classes of compounds made data review and processing significantly easier since spectra from different regions of the TLC plate could be processed individually. This multidimensional approach offers great potential for detailed studies of highly complex petroleum samples. Further work will include investigation of additional DESI spray solvent systems to enhance extraction of less polar sample components, and comparisons between the separations achieved using different HPTLC phases and different elution solvents.