LC/MS/MS Analysis with On-line Cartridge for Removal of Phospholipids from Protein Precipitation Biological Fluid Samples

摘要

An on-line cartridge packed with zirconia-coated silica particles has been successfully developed for the on-line phospholipid removal during LC/MS analysis of biological samples. Performance testing shows the on-line cartridges are capable of removing >95% of phospholipids from a 1 μL of plasma samples even after 120 consecutive injections.