Utility of high resolution MALDI imaging in drug discovery: Histological distribution of gentamicin in proximal renal tubules of rats

摘要

In pharmacology and toxicology, localization of a drug molecule in the target tissue of organs provides very important in vivo biological information. Imaging mass spectrometry is increasingly used in drug discovery and development during preclinical studies. Gentamicin is an antibiotic to treat infections, but it possesses renal toxicity. As it is excreted in the urine, the kidney tissues of a person being treated with gentamicin are almost constantly bathed in gentamicin. The objective of the study is to define the specific distribution of the parent drug in proximal renal tubules of rats dosed gentamicin using MALDI imaging.