A Hybrid MSI Method Combining MALDI and NIMS for Small Molecule Discovery and Identification inCrustacean Brain Tissue

摘要

HRAM MALDI-MS demonstrates its unique ability in direct molecule localization NIMS showed superior performance in analyzing acetylcholine standard compared to MALDI MS NIMS Imaging and MALDI MSI generated comparable results for lipid analytes NIMS on HRAM MALDI-MS platform for tissue analysis is under development Future Studies: To perform HRAM NIMS profiling and imaging on crustacean neuronal tissue To apply ion mobility separation on NIMS by MALDI SynaptG2 mass spectrometer.