首页> 外国专利> A method for maldi - msi analysis of objects, in particular biological tissue samples, and the target for the analysis as well as its production

A method for maldi - msi analysis of objects, in particular biological tissue samples, and the target for the analysis as well as its production

机译:一种对象(特别是生物组织样品)以及待分析对象及其生产的恶意分析方法

摘要

The object of the invention was in the case of the maldi - msi - analysis of an object of one or several analyte classes extensively as possible, with little effort and low duration of administration, without the signal quality with respect to intensity, localization and differentiability and without impairing the dyeing is possible for an optical scan of the tissue section to be reduced, wherein an exact histogram morpho logical comparability for a localization related evaluation analysis is to be made possible by means of engaging.According to the invention, a target (1), on which the object to be examined is to be applied, with a plurality of different matrix grids (2, 3) in the offset relative to one another in each case coated. For each matrix network (2, 3), at least one analysis grid in each case separately measured. The separately measured analysis grid specific data sets are in their entirety, as well as with object covering the same position reference evaluated.
机译:本发明的目的是在对一种或几种分析物类别的对象进行马尔代-msi分析的情况下,尽可能少地付出努力和低施用时间,而没有关于强度,定位和可区分性的信号质量。并且在不损害染色的情况下减少组织切片的光学扫描是可能的,其中通过接合使得与定位相关的评估分析的精确直方图形态可比性成为可能。在图1中示出的实施例中,将要检查的物体施加在其上,在其上分别涂覆有相对于彼此偏移的多个不同的矩阵栅格(2、3)。对于每个矩阵网络(2、3),分别分别测量至少一个分析网格。单独测量的分析网格特定数据集是完整的,并且对象覆盖了评估的同一位置参考。

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