This work demonstrates the potential of the Timepix for more rapid and sensitive detection of native-MS produced protein complexes. Spectra with similar signal-to-noise can be acquired in an order of magnitude fewer ion pulses. The utility of the Timepix will be further enhanced with the next generation Timepix which will significantly improve on time resolution, and multi-hit capabilities. A 1KHz read out system is also under development which will greatly increase the speed of analysis. In addition, duty cycle enhancement is targeted through the incorporation of an accumulation region prior to ions entering the pusher region are also planned. Such developments, for example, may find use in the coupling with rapid chromatographic separations of proteins. Finally, the Timepix, by also providing the ion impact positons on the detector, also allows the investigation and visualization of the metastable decay of large complexes, thus also providing insight into the energetics of ion production and transport.
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