Direct analysis of 10 antipsychotics in serum by the online system integrating solid-phase extraction with UHPLC-MS/MS

摘要

A fully-automatic versatile SPE-UHPLC-MS/MS system was successfully applied to the direct analysis of ten Aps in serum. Excellent repeatability, low LODs and satisfactory recoveries were obtained under the optimized conditions. In conclusion, the online SPE-UHPLC-MS/MS system is a simple and effective technique for the automatically analysis of trace compounds in complex matrix.