Analysis of N-nitrosamines in water by Gas Chromatography, Electron Ionization Tandem Mass Spectrometry

摘要

The enhanced EI sensitivity of the HES ion source of new generation GC-MS/MS systems meets and exceeds the detection requirements of EPA Method 521, providing a good alternative to the now unavailable PCI MS/MS Ion Trap systems. The rapid EI/MS/MS method was applied to the analysis of samples over several days to validate the application and confirm the stability of the method. The generated results established that EI/MS/MS mode has excellent detection levels ranging from 0.08 - 0.4 ng L~(-1) with only a 0.5 μL sample injection, well below the required levels. The small injection volume led to less sample on column, less concentration of the sample and less maintenance on the total system. Results of calibration in the 1-20ng L~(-1) range and recoveries at multiple levels all demonstrated highly sensitive, accurate and reliable performance.