Analysis of Fentanyl and Its Analogues in Human Urine by LC-MS/MS

摘要

Synthetic opioid drugs, such as fentanyl and sufentanil, have very high analgesic potency. Abuse of these prescription opioids and their illicit analogue, acetyl fentanyl, is a growing public health problem. In this study, a simple dilute and shoot method was developed with an analysis time of less than 3.5 minutes for fentanyl, norfentanyl, acetyl fentanyl, and sufentanil in human urine by LCMS/ MS using the Raptor Biphenyl column.