Derivatization of N-linked Glycans for Sensitive Detection by MALDI-TOF MS toward Glyco-Biomarker Discovery

摘要

Our purpose is development of a novel derivatization which combines permethylation and the reducing end labeling to achieve a high sensitive detection of N-linked glycans using MS. The novel derivatization could contribute to sensitive detection of glycans by MS. This method will be a poeerful tool for glyco-biomarker discovery.