Proteome Measurements towards Understanding Parkinson Disease Utilizing Drosophila Models

摘要

Results from internal standard proteins as well as Western blot analysis indicate that the employed proteomic approaches accurately predict relative protein expression. A comparison of Drosophila proteome responses to the three alpha-synuclein genes indicates that there is low overlap among the differentially expressed proteins. Fat body protein 1 may offer a general biomarker for the diagnosis of presymptomatic PD in the Drosophila models. Protein interaction network analysis indicates that many dysregulated proteins are involved in a single complex network, which may provide insight into molecular pathways underlying PD at the presymptomatic stage.