Evaluation of MS/MS Methods: CID, PQD and HCD in an LTQ-Orbitrap Mass Spectrometer for Structural Elucidation of Metabolites

摘要

Overall, PQD provided more fragmentation than that by CID or HCD as demonstrated with the metabolites/analogs of loratadine, and vicriviroc. In the analyses of cocaine and tolbutamide related standards, CID and PQD gave comparable results, perhaps superior to that of HCD.