Probing conformational changes in peptide hormones complexed with transition metal cations using electron capture dissociation (ECD)

摘要

OT and VP show different ECD behavior in various metal-complexed species. Upon opening of the tocin ring, ECD of OT and VP changes. ETD of peptide complexes can yield complementary fragments. PTR allows for the generation of singly charged peptides containing doubly charged metal cations (Cu~(2+) and Zn~(2+)).