Identification of Platelet Factor-4 as an Indicator of Blood Count Recovery in Acute Myeloid Leukemia Patients in Complete Remission

摘要

We have demonstrated, using an combined proteomic technology of MB-based MALDI profiling, MS/MS analysis and protein molecular weight analysis, that serum PF4 levels in AML patients return to or are elevated above the normal level in patients achieving CR, whereas in RD patients, levels were unchanged or decreased below the normal level. From our results, PF4 was shown to be a good indicator for the recovery of blood count in the complete remission of AML. In further study, we are going to detect this indicator protein, PF4 by using multiple ion reaction monitoring (MRM) approach.