Rapid Screening and Identification of Chemical Warfare Agents in Environmental Samples using LC/MS and a MS/MS-Library

摘要

Non-target screening: Using in-source CID in the QTRAP-ESI source. Target screening: Multiple Reaction Monitoring (MRM) mode. LC/MS - and MS/MS-libraries: 1. In-source CID mass spectral library. 2. MS/MS-library of spectra obtained in the enhanced product ion mode of the ion trap instrument. Spectra at collision energies of 20, 35 and 50 eV are compatible with spectra obtained on triple quad instruments. The screening procedures and the libraries were successfully applied in recent proficiency tests conducted by the Organization for the Prohibition of Chemical Weapons (OPCW).