SOURCES OF HIGH PRESSURE IN MICROWAVE ASSISTED SYNTHESIS OF NOVEL FORMAMIDE FUNGICIDES

摘要

Microwave-assisted Leuckart reaction comprises a convenient method for synthesis of novel formamide fungicides. However, a high pressure developing during the reaction makes it impossible to use the existing reaction vessels designed for automated microwave synthesis. In this work the factors influencing the high pressure were investigated. It was found that most of the pressure is produced not by the reaction itself but by formic acid that is used as an additive to accelerate the reaction. The results of the work suggest that the problem of high pressure in microwave assisted Leuckart reaction should be specifically addressed at the hardware level.