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Spatial and temporal variability in myocardial contrast enhancement after intravenous echocontrast injection

机译:静脉内棘上注射术后心肌对比度增强的空间和时间变异性

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摘要

Aim of the study was to assess whether spatial and temporal variability in myocardial echo contrast enhancement limits the study of myocardial perfusion. Four open chest dogs were studied at baseline and during left circumflex coronary artery occlusion using 2D echo with harmonic intermittent imaging after intravenous injection of a contrast agent. Mean gray level intensity was measured in the anterior, lateral inferior and septal myocardium on digital images at 8, 15 and 22 sec after contrast appearance in the left ventricle. Myocardial enhancement was seen after 15 sec in the 4 walls: at 8 sec, increase in mean intensity was found in the lateral wall only. After 22 sec, difference in mean intensity from pre-contrast was significant for all walls but the inferior. During coronary occlusion, decrease in mean intensity compared to basal was seen in the ischemic wall, most significant at 22 sec. After intravenous injection of echo contrast, regional and temporal variability in myocardial enhancement may interfere with quantitative perfusion measures.
机译:该研究的目的是评估心肌回波对比度增强的空间和时间变异是否限制了心肌灌注的研究。在基线和静脉期间回声静脉注射造影剂后的谐波间歇成像期间,在基线和左循环冠状动脉闭塞期间进行了四条开放的胸犬。在左心室鲜明外观后8,15和22秒的数字图像上的前,侧向劣质和隔膜心肌中测量了平均灰度强度。在4壁中15秒后看到心肌增强:在8秒,仅在侧壁中发现平均强度的增加。 22秒后,对比度的平均强度的差异对于所有墙壁来说都是显着的,但是劣质。在冠状动脉闭塞期间,在缺血壁上看到与基底相比的平均强度下降,在缺血壁上,最显着的22秒。在静脉注射回声对比后,心肌增强中的区域和时间变异可能会干扰定量灌注措施。

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