Role of NADPH Oxidase in Radiation-induced Oxidative Stress and Inflammation in Brain Endothelium

摘要

The need to understand and minimize the side effects of whole brain irradiation (WBI) is exacerbated by the increasing number of patients with brain metastases requiring WBI, -200,000 patients/year,. We hypothesize that WBI leads to activation of the intrinsic renin-angiotensin system (RAS) and induction of proinflammatory mediators regulated via the downstream NADPH oxidase signaling pathway. Irradiating RBMECs increased intracellular ROS generation, NFkB activation, and PAI-1 and ICAM-1 expression, which were ameliorated by inhibition of NADPH oxidase.